Matthew Fraley
Graduate Assistant, School of Natural Science and Mathematics
Researching under Assistant Professor Patrick Lombardi, Ph.D., Abigal Hacker sought to understand the ASCC2 DNA repair complex in order to “gain insight [into] alkylation-induced damage repair” and potentially provide ways to mitigate the effects of cancer and chemotherapy.
The School of Natural Science and Mathematics annually offers the SRIA, or Student Research Internship Award, program that gives selected students the opportunity to conduct research in university facilities over the summer. The students work closely with faculty advisors to gain an optimal research experience. SRIA scholars are carefully chosen based on a research proposal that the student submits to the dean of natural science and mathematics. Last summer four students conducted research on optogenetics, DNA repair and acoustic wave agitation.
Chardane LoganChardane Logan worked with Assistant Psychology Professor Angy Kallarackal, Ph.D., to study creating a memory using optogenetics. Optogenetics is a biological technique that involves using light to control neurons that have been modified to express light-sensitive ion channels. She shared that her research helped her to grow in "confidence and resilience” through voicing her opinions and honing her skills in handling the subjects during the study. She also said that her growth in confidence and resilience will benefit her greatly as she continues to conduct research heading into graduate school.
Abigail Hacker researched under Assistant Chemistry Professor Patrick Lombardi, Ph.D., on the topic of determining the structural basis of ASCC2 selectivity. Her research was designed to understand ASCC2 DNA repair complex in order to “gain insight [into] alkylation-induced damage repair” and potentially provide ways to mitigate the effects of cancer and chemotherapy. “While this experience has strengthened my prior knowledge, it has also challenged me to understand and accomplish tasks that I have never faced before,” Hacker said. After graduation, she plans to pursue a Doctorate of Medicine, and this research experience helped build toward that goal. “This internship has also allowed me to build my resume and pursue future fellowships to further my knowledge of the biochemical and medical fields,” she said.
Lauren GrayIn also working with Professor Lombardi, Lauren Gray studied how cells repair DNA damage. Gray’s research involved many new techniques for her research topic, including DNA mutagenesis, protein purification, and isothermal titration calorimetry. "Experiencing the day-to-day rigors of a lab helped me to prepare for a promising career in science and affirmed that I do want to work in a lab in my professional career,” Gray said. “The SRIA award also gave me an authentic laboratory experience that I would not have been able to receive elsewhere.”
Matthew Fraley
Graduate Assistant, School of Natural Science and Mathematics